Karen M. Perl, MD

Dr. Karen Perl, DO, is a highly respected pain medicine physician with more than 25 years of clinical experience specializing in musculoskeletal health, chronic pain management, and advanced non-surgical regenerative therapies. Known for her compassionate approach and exceptional diagnostic insight, Dr. Perl has earned recognition from patients and peers across the country for her expertise in evaluating and treating complex pain conditions.

Dr. Perl graduated from the University of North Texas Health Science Center – Texas College of Osteopathic Medicine, one of the most distinguished DO programs in the nation. Her osteopathic training emphasizes whole-person care, functional movement, and the interconnectedness of the musculoskeletal system — principles that continue to guide her approach to modern regenerative medicine.

Over her career, she has served in multiple high-level clinical settings and is affiliated with CHRISTUS Mother Frances Hospital–Tyler, where she has worked alongside multidisciplinary teams treating a wide range of pain and mobility-related conditions. Her experience spans spine disorders, joint pain, nerve-related issues, soft-tissue injuries, and complex chronic pain syndromes.

Dr. Perl is widely known for her ability to blend traditional pain management expertise with emerging regenerative approaches. Her unique combination of clinical intuition, advanced procedural skills, and commitment to ongoing education has positioned her as a leading physician for individuals seeking high-quality, non-surgical solutions for pain and mobility.

Areas of expertise include:

• Chronic and acute pain conditions
• Spine-related pain, including cervical and lumbar issues
• Joint pain involving the shoulder, knee, hip, and ankle
• Nerve-related pain and mobility impairments
• Soft-tissue injuries and repetitive strain conditions
• Biologic and regenerative pain management strategies
• Non-surgical mobility, function, and wellness optimization

Patients describe Dr. Perl as caring, thorough, and exceptionally dedicated, with a rare ability to listen deeply, understand root causes, and design personalized treatment pathways that align with each individual’s goals and lifestyle.

With more than two decades of experience and a practice grounded in both medical science and compassionate care, Dr. Perl is considered one of the most trusted regenerative and pain medicine physicians serving the region today.

‍